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NEW: USOR 18042 A Phase 2, Non-Randomized, Open Label, Single Arm, Multi-Center Study Of Talazoparib For Neoadjuvant Treatment Of Germline BRCA 1/2 Mutation Patients With Early Triple-Negative Breast Cancer. (C3441020)

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 17162 A Phase II, Randomized, Blinded, Placebo-Controlled Study, of MTIG7192A, an Anti-Tigit Antibody, in Combination with Atezolizumab in Chemotherapy Naive Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC.) USOR 17162/GO40290

Disease Types: Lung, Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


USOR 16187: A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-Line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen (AM0010-301) USOR 16187

Disease Types: Pancreas
Available at: Arlington Heights, Niles


USOR 17186: An Open-Label Exploratory Phase 2/3 Study of Nivolumab with Standard of Care Therapy versus Standard of Care Therapy For First Line Treatment of Metastatic Colorectal Cancer. (CA209-9X8) (USOR 17186)

Disease Types: Colorectal
Available at: Arlington Heights, Niles


USOR 17063/TSR-022: A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-022, an Anti-TIM-3 Monoclonal Antibody, in Patients with Advanced Solid Tumors: NSCLC. USOR 17063 (4020-01-001)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


USOR 17050 A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Efficacy and Safety of Polatuzumab Vedotin in Combination with Rituximab and CHP (R-CHP) versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients with Diffuse Large B-Cell Lymphoma (DLBCL.) USOR 17050/GO39942. Contact Project Manager Status.

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 17093/CITADEL-205 A Phase 2, Open-Label, 2-Cohort, Multicenter Study of INCB050465, a PI3Ka Inhibitor, In Relapsed or Refractory Mantle Cell Lymphoma Previously Treated With or Without a BTK Inhibitor (CITADEL-205) - INCB050465-205.

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 16023 An International, Multi-Center, Open-Label, Randomized, Phase III Trial of Sacituzumab Govitecan versus Treatment of Physician Choice in Patients with Metastatic Triple-Negative Breast Cancer Who Received at Least Two Prior Treatments. (IMMU-132-05)

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 17081 An Open-Label, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Ixazomib (NINLARO) in Combination with Lenalidomide and Dexamethasone (IRD) in Patients with Multiple Myeloma Previously Receiving a Bortezomib-Based Triplet Induction Regimen. USOR 17081 (C16038) Ph4 Ixazomib+Lena & Dex MM (MM-6)

Disease Types: Multiple Myeloma
Available at: Arlington Heights, Niles


USOR 16164 Randomized, Multi-Center, Open-Label, Phase 3, Study of Nivolumab in Combination with Oxaliplatin Plus Fluoropyrimidine vs. Oxaliplatin Plus Fluoropyrimidine in Subjects with Previously Untreated, Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer. (BMS CA 209-649)

Disease Types: Gastric, Gastric/Gastroesophageal
Available at: Arlington Heights, Niles


USOR 16195 A Phase 2, Randomized, Double-Blinded, Controlled Study of Tucatinib vs. Placebo in Combination with Capecitabine and Trastuzumab in Patients with Pretreated, Unresectable, Locally Advanced or Metastatic HER2+ Breast Carcinoma. USOR 16195 (STAR ONT 380 206)

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 17082 A Randomized, Open-Label, Phase 3 Study for Patients With Node-Positive, Early Stage, HR+, HER2-, Breast Cancer. MonarchE is a Phase 3 Study of Abemaciclib Combined with Standard Adjuvant EndocrineTherapy vs Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer. USOR 17082 (I3Y-MC-JPCF) (Monarche)

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 17041 Screening Protocol for STAR USOR 16248: An Open-Label, Multicenter, Phase 1/2 Study of Tazemetostat (EZH2 Histone Methyl Transferase [HMT] Inhibitor) as a Single Agent in Subjects With Advanced Solid Tumors or With B Cell Lymphomas and Tazemetostat in Combination With Prednisolone in Subjects with Diffuse Large B Cell Lymphoma. USOR 17041

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 16041 AN OPEN-LABEL PHASE 2 MULTI-COHORT TRIAL OF NIVOLUMAB IN ADVANCED OR METASTATIC MALIGNANCIES. HOLDING. CONTACT RESEARCH FOR OPEN COHORTS. USOR 16041 (CA 209-627)

Disease Types: Solid Tumor
Available at: Arlington Heights, Niles


AGIOS AG120-C-009 A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of AG-120 in Combination with Azacitidine in Subjects 18 Years of Age and Older, with Previously Untreated Acute Myeloid Leukemia with an IDH1 Mutation.

Disease Types: Leukemia
Available at: Arlington Heights, Niles


ECOG-ACRIN S1400 2nd Line A Phase II/III, Biomarker-Driven Master Protocol For Previously Treated Squamous Cell Lung Cancer. - A Phase II Study of Talazoparib in Patients with Homologous Recombination Repair Deficiency Positive Stage IV Squamous Cell Lung Cancer. - A Phase III Randomized Study of Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients with Stage IV Squamous Lung Cancer and No Matching Biomarker.

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


ECOG-ACRIN-4512 A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib vs Placebo for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein.

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


ECOG-ACRIN 1910 A Phase III, Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL Negative B Lineage Acute Lymphoblastic Leukemia in Adults.

Disease Types: Leukemia
Available at: Arlington Heights, Niles


ECOG-ACRIN S1207 A Phase III, Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/Neu Negative Breast Cancer.

Disease Types: Breast
Available at: Arlington Heights, Niles


ECOG-ACRIN 1131 A Randomized, Phase III Post-Operative Trial of Platinum Base Chemotherapy vs Observation in Patients with Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Therapy.

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 16140 GRAIL 001 THE CIRCULATING CELL-FREE GENOME ATLAS STUDY (CCGA.) A Prospective, Multi-Center, Observational Study with Collections of De-Identified Biospecimens and Clinical Data from at Least 10,000 Participants from Clinical Networks in the United States, Canada and the United Kingdom. Next Generation Sequencing (NGS) based assay(s) of Nucleic Acids (NAs) Isolated From Peripheral Blood and Tumor Tissues.

Disease Types: Solid Tumor
Available at: Arlington Heights, Niles


USOR 16035 Registry - A Global, Prospective, Non-Interventional, Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Patients - The Insight MM Study. (NSMM-5001)

Disease Types: Multiple Myeloma
Available at: Arlington Heights, Niles


USOR 16065 Relapsed/Refractory - A Phase 2b, Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 and TGR-1202 Alone in Patients with Previously Treated Diffuse Large B-Cell Lymphoma. (UTX-TGR-205)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 11282 1st Line - A Phase 2, Single-Arm, Open-Label Study of Single-Agent Brentuximab Vedotin for Front-Line Therapy of Hodgkin Lymphoma (HL) in Adults Age 60 and Above.(SGN35-015)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 16100 Hodgkins Lymphoma Molecular Profiling and Clinical Outcomes in U.S. Community Oncology Practices. (CA20965)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


USOR 16156 A Phase IIIb/IV Safety and Efficacy Trial of Flat Dose Nivolumab in Combination with Ipilimumab in Participants with Non-Small Cell Lung Cancer. (CA209-817)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


USOR 16161 A Randomized, Open-Label, Phase 3 Trial of Nivolumab and Ipilimumab Versus Platinum-Doublet Chemotherapy in Early Stage NSCLC. (CA209-816)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


USOR 16128 POLARIS: Palbociclib in Hormone Receptor Positive Advanced Breast Cancer: A Prospective Multicenter Non-Interventional Study. (A5481081)

Disease Types: Breast
Available at: Arlington Heights, Niles


USOR 08160 PNH Registry: Primary Objective of the Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry will Collect Data to Evaluate Safety Data Specific to the Use of Solaris and to Characterize the Progression of PNH as well as Clinical Outcomes, Mortality and Morbidity in Solaris and Non-Solaris Treated Patients. Secondary Objective is Raising PNH Awareness in the Medical Community and Patient/Potential Patient Population. (M07-001)

Disease Types: Hematology, PNH
Available at: Arlington Heights, Niles