Industry News
News From The Journal Of Clinical Investigation: Dec. 21, 2012
Dec 24, 2012
The X-factor in liver metabolism After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch... Read More
"Trojan Horse" Cancer Treatment Eliminates Cancer In Mice
Dec 24, 2012
An experimental treatment that uses white blood cells like "Trojan horses" to carry a tumor-busting virus, completely abolished prostate cancer spread after chemo or radiotherapy in mice. The researchers hope clinical trials in human patients with prostate cancer can start in early 2013... Read More
Researchers Find Model System To Study Promising Cancer Drug
Dec 24, 2012
Researchers have found that the budding yeast (Saccharomyces cerevisiae) is an acceptable model system to study KP1019, an anti-cancer drug that uses ruthenium, a rare metal, a new study found. Researchers had previously been interested in studying KP1019 because it is believed to cause cancer cell death and is not known to have negative secondary side effects for healthy tissues... Read More
New Technology Allows Scientists To Capture And Preserve Cancer Cells Circulating In The Bloodstream
Dec 24, 2012
Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream... Read More
Changes In Progenitor Cell Population In Breast May Be Overlooked Factor In Breast Cancer
Dec 24, 2012
The DNA mutations that accumulate over time as women age are not the sole contributor to the higher frequency of breast cancer in women over 50, Mark LaBarge, PhD, a researcher at Lawrence Berkeley National Laboratory (LBNL) reported on Dec. 17 in a presentation at the American Society for Cell Biology Annual Meeting in San Francisco... Read More
To Revert Breast Cancer Cells, Give Them The Squeeze
Dec 24, 2012
Researchers at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory have put the squeeze - literally - on malignant mammary cells to guide them back into a normal growth pattern. The findings, presented Monday, Dec... Read More
Study Uncovers Mechanism Used By BRCA1 To Suppress Tumors
Dec 24, 2012
A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. The findings, published online in Oncogene, focus on the gene BRCA1, which is mutated in a majority of families who have hereditary breast and/or ovarian cancers, according to senior author Ronit I... Read More
Surviving Sepsis With LECT2
Dec 24, 2012
Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th. Bacterial sepsis is a potentially deadly blood infection that results in massive immune activation and inflammation. Sepsis therapies have traditionally focused on quelling this exaggerated inflammatory response... Read More
UK Colonoscopy Guidelines May Better Identify High-Risk Patients
Dec 23, 2012
Colonoscopy guidelines from the United Kingdom may better identify patients who need short-interval follow-up screening compared to guidelines from the United States. Researchers analyzed four prospective studies of 3,226 postpolypectomy patients to compare risk for advanced colorectal neoplasia at one-year colonoscopy. Patients were cross-classified by U.S. and U.K. surveillance guidelines... Read More
Harnessing The ID In Glioma
Dec 23, 2012
Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural stem cells. GICs drive tumor progression and must stay in a particular extracellular niche in order to maintain their cancer-promoting, stem cell-like characteristics... Read More
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