Industry News
BRAF mutation associated with other cancers appears to drive papillary craniopharyngiomas
Jan 15, 2014
A team led by investigators from Massachusetts General Hospital (MGH), Brigham and Women's Hospital (BWH) and the Broad Institute has found that a gene mutation associated with several types of cancer also may be responsible for a rare but debilitating brain tumor called papillary craniopharyngioma. Read More
Regorafenib: hint of minor added benefit
Jan 15, 2014
Advantage in overall survival, but disadvantage in severe side effectsRegorafenib (trade name: Stivarga) has been approved in Germany since August 2013 for adults with metastatic colorectal cancer in whom previous treatments are no longer effective or for whom these alternatives are not an option. Read More
Follow-up tests improve colorectal cancer recurrence detection
Jan 14, 2014
Among patients who had undergone curative surgery for primary colorectal cancer, the screening methods of computed tomography and carcinoembryonic antigen each provided an improved rate of surgical treatment of cancer recurrence compared with minimal follow-up, although there was no advantage in combining these tests, according to a study in the January 15 issue of JAMA. Read More
Patients with mild hyperglycemia and genetic mutation have low prevalence of vascular complications
Jan 14, 2014
Despite having mild hyperglycemia for approximately 50 years, patients with a mutation in the gene encoding the enzyme glucokinase had a low prevalence of clinically significant vascular complications, findings that provide insights into the risks associated with isolated mild hyperglycemia, according to a study in the January 15 issue of JAMA. Read More
Follow-up tests improve colorectal cancer recurrence detection
Jan 14, 2014
Among patients who had undergone curative surgery for primary colorectal cancer, the screening methods of computed tomography and carcinoembryonic antigen each provided an improved rate of surgical treatment of cancer recurrence compared with minimal follow-up, although there was no advantage in combining these tests, according to a study in the January 15 issue of JAMA. Read More
Mechanism affecting risk of prostate cancer is found
Jan 14, 2014
A research group at Biocenter Oulu in Finland has identified a mechanism related to a transcription factor that binds much more strongly onto a particular SNP variant, thereby initiating a genetic programme which enhances prostate cancer proliferation and metastasis. Read More
Looking younger for longer
Jan 14, 2014
Newcastle University researchers have identified an antioxidant Tiron, which offers total protection against some types of sun damage and may ultimately help our skin stay looking younger for longer. Read More
The structure revealed of master regulator and new drug target for autism, cervical cancer
Jan 14, 2014
A team of scientists at LSU Health Sciences Center New Orleans has discovered the structure of the active form of E6-associated protein (E6AP), an enzyme that acts as a master regulator in the body. They report, for the first time, that the active form of E6AP is composed of three distinct protein molecules. Read More
Autophagy predicts which cancer cells live and die when faced with anti-cancer drugs
Jan 14, 2014
When a tumor is treated with an anti-cancer drug, some cells die and, unfortunately, some cells tend to live. A University of Colorado Cancer Center study published in the journal Nature Cell Biology details a possible difference between the susceptible and resistant cells: the rate at which cells are able to cleanse themselves via the process known as autophagy. Read More
Preventing therapy resistance in tumor cells
Jan 14, 2014
A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments. Read More
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