Industry News
News From The Journal Of Clinical Investigation: Nov. 7, 2011
Nov 08, 2011
ONCOLOGY: Stopping breast cancer spread Most people who die from breast cancer do not die as a result of their breast tumor but because their cancer has spread (metastasized) to other parts of their body, often their lungs or bones... Read More
Possible Personalized Brain Tumor Therapy With Src Inhibitors Following Discovery That Metabolic Protein Plays Role In Tumor Cell Formation And Growth
Nov 08, 2011
The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation... Read More
Some Colon Tumors Caused By Common Bacteria Altering Peroxide-Producing Gene
Nov 08, 2011
Working with lab cultures and mice, Johns Hopkins scientists have found that a strain of the common gut pathogen Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO) in the intestine... Read More
Radiotherapy Added To Hormone Treatment May Prevent Many Prostate Cancer Deaths
Nov 07, 2011
Results from a large study have shown that combining radiotherapy and hormone therapy in patients with prostate cancer significantly improved men's survival compared with hormone therapy treatment alone. The study was conducted by the Medical Research Council (MRC) in collaboration with the NCIC Clinical Trials Group located at Queen's University in Kingston, Canada... Read More
Female Lung Cancer Rates Rise While They Drop For Males
Nov 07, 2011
According to Cancer Council Australia, new research shows increased lung cancer rates in Australian women, adding urgency to further de-glamorize tobacco smoking. The research should plead an urgent call for the federal Parliament's passage of plain packaging for tobacco bills... Read More
Identification Of Two Molecules That Kill Lymphoma Cells In Mice Generates Potential For New Anti-Cancer Therapies
Nov 07, 2011
Researchers at the University of Southern California have identified two molecules that may be more effective cancer killers than are currently available on the market. The peptides, molecules derived from a cancer-causing virus, target an enzyme in cancerous cells that regulates a widely researched tumor suppressor protein known as p53... Read More
Critical Step To Opening Elusive Class Of Compounds To Drug Discovery Achieved By Scripps Research Team
Nov 07, 2011
Taxanes are a family of compounds that includes one of the most important cancer drugs ever discovered, Taxol®, among other cancer treatments. But the difficulty producing these complex molecules in the lab has hampered or blocked exploration of the family for further drug leads... Read More
Discovery Of Genes Involved In Colorectal Cancer
Nov 07, 2011
A jumping gene with the fairy tale name "Sleeping Beauty" has helped to unlock vital clues for researchers investigating the genetics of colorectal cancer. A study published Nov 6th used the Sleeping Beauty transposon system to profile the repertoire of genes that can drive colorectal cancer, identifying many more than previously thought... Read More
New Findings Suggest That Activation Of The PKM2 Enzyme May Sensitize Cancer Cells To Oxidative Stress
Nov 05, 2011
It has long been known that cancer cells use nutrients differently than normal cells. In recent years, the rapidly reemerging field of cancer metabolism has shed new light on the ways that cancers use glucose to grow and thrive, demonstrating that manipulation of an enzyme called PKM2 is important to this metabolic process... Read More
Living On Without Telomerase
Nov 04, 2011
Scientists of the German Cancer Research Center have discovered an alternative mechanism for the extension of the telomere repeat sequence by DNA repair enzymes. The ends of the chromosomes, the telomeres, are repetitive DNA sequences that shorten every time a cell divides during the process of duplicating its genome. Once the telomeres become very short the cell stops dividing... Read More
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