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NEW TRIAL - ICS IS THE FIRST SITE TO OPEN ENROLLMENT FOR AG-120-C-009. A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of AG-120 in Combination with Azacitidine in Subjects 18 Years of Age and Older, with Previously Untreated Acute Myeloid Leukemia with an IDH1 Mutation. (AG120-C-009)

Disease Types: Leukemia
Available at: Arlington Heights, Niles


A Phase II/III, Randomized Stuyd of AZD4547 vs Docetaxel as Second Line Therapy For FGFR-Positive Patients With Stage IV Squamous Cell Lung Cancer. (ECOG-ACRIN S1400)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib vs Placebo for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein. (ECOG-ACRIN 4512)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


A Phase III, Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL Negative B Lineage Acute Lymphoblastic Leukemia in Adults. (ECOG-ACRIN 1910)

Disease Types: Leukemia
Available at: Arlington Heights, Niles


A Randomized, Phase II Study of Irinotecan and Cetuximab With or Without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), In Advanced, K-RAS Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy. (ECOG-ACRIN 7208)

Disease Types: Colorectal
Available at: Arlington Heights, Niles


A Phase III, Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/Neu Negative Breast Cancer. (ECOG-ACRIN S1207)

Disease Types: Breast
Available at: Arlington Heights, Niles


A Randomized, Phase III Post-Operative Trial of Platinum Base Chemotherapy vs Observation in Patients with Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Therapy. (ECOG-ACRIN 1131)

Disease Types: Breast
Available at: Arlington Heights, Niles


A Prospective, Multi-Center, Observational Study with Collections of De-Identified Biospecimens and Clinical Data from at Least 10,000 Participants from Clinical Networks in the United States, Canada and the United Kingdom. Next Generation Sequencing (NGS) based assay(s) of Nucleic Acids (NAs) Isolated From Peripheral Blood and Tumor Tissues. (The Circulating Cell-Free Genome Atlas (CCGA) Study GRAIL-001) (USO 16140)

Disease Types: Solid Tumor
Available at: Arlington Heights, Niles


A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (KEYNOTE-564) (USO 16251)

Disease Types: Renal
Available at: Arlington Heights, Niles


Phase 3b/4 Safety Trial of Nivolumab Combined with Ipilimumab in Subjects with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma. (CA209-920) (USO 16177)

Disease Types: Renal
Available at: Arlington Heights, Niles


A Multicenter, Open-Label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects with Advanced Renal Cell Carcinoma. (E7080-G000-307) (CLEAR) (USO 16145)

Disease Types: Renal
Available at: Arlington Heights, Niles


Prospective Observational Study in Patients with Locally Advanced or Metastatic Gastroenteropancreatic Neuroendocrine TumorsTreated with Lanreotide Depot in a U.S. Community Oncology Setting. (Ipsen A-US-52030-340) (USO 15051)

Disease Types: Neuroendocrine
Available at: Arlington Heights, Niles


A Global, Prospective, Non-Interventional, Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Patients - The Insight MM Study. (NSMM-5001) (USO 16035)

Disease Types: Multiple Myeloma
Available at: Arlington Heights, Niles


Daratumumab Plus Cyclophosphamide, Bortezomib and Dexamethasone (Dara-CyBorD) in Previously Untreated and Relapsed Subjects with Multiple Myeloma. (547674MMY2012) (USO 16084)

Disease Types: Multiple Myeloma
Available at: Arlington Heights, Niles


A Phase 3B Randomized Study of Lenalidomide Plus Rituximab Maintenance Therapy Followed by Lenalidomide Single-Agent Maintenance Versus Rituximab Maintenance in Subjects with Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma. (CC-5013-NHL-008) (USO 13064)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


A Phase 2b, Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 and TGR-1202 Alone in Patients with Previously Treated Diffuse Large B-Cell Lymphoma. (UTX-TGR-205) (USO 16065)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


A Phase 2, Open-Label Study of Brentuximab Vedotin in Front-Line Therapy of Hodgkin Lymphoma (HL) in Adults Age 60 and Above. (SGN35-015) (USO 11282)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


A Phase III, Randomized, Open-Label, Clinical Trial to Compare Pembrolizumab with Brentuximab Vedotin in Subjects with Relapsed or Refractory Classical Hodgkin Lymphoma. (MK-3475-204) (USO 15223)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


Hodgkins Lymphoma Molecular Profiling and Clinical Outcomes in U.S. Community Oncology Practices. (CA20965) (USO 16100)

Disease Types: Lymphoma
Available at: Arlington Heights, Niles


A Master Protocol of Phase 1/2 Studies of Nivolumab in Advanced NSCLC Using Nivolumab as Maintenance After Induction Chemotherapy or as a First-Line Treatment Alone or In Combination with Standard of Care Therapies (USO 14158)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


A Dose Frequency Optimization, Phase IIIB/IV Trial of Nivolumab 240mg Every 2 Weeks vs Nivolumab 480mg Every 4 Weeks in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer who Received up to 12 Months of Nivolumab at 3mg/kg or 240mg Every 2 Weeks. (CheckMate384-CA209384) (USO 15203)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


A Phase IIB/IV Trial of Flat Dose Nivolumab in Combination with Ipilimumab in Participants with NSCLC (CA209-817) (USO 16156)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


Randomized, Open-Label, Phase 3 Trial of Nivolumab and Ipilimumab Versus Platinum-Doublet Chemotherapy in Early Stage NSCLC (CA209-816) (USO 16161)

Disease Types: Lung - Non-Small Cell Lung
Available at: Arlington Heights, Niles


Phase 3, Randomized Study to Assess the Efficacy and Safety of Ublituximab in Combination with TGR-1202 Compared to Obinutuzumab in Combination with Chlorambucil in Patients with Chronic Lymphocytic Leukemia (CLL) (USO 15229)

Disease Types: Leukemia
Available at: Arlington Heights, Niles


Polaris: Palbociclib in Hormone Receptor Positive Advanced Breast Cancer: A Prospective Multicenter Non-Interventional Study (A5481081) (USO 16128)

Disease Types: Breast
Available at: Arlington Heights, Niles


Phase 2 Study of the Safety, Efficacy, and Pharmacokinetics of G1T28 in Patients with Metastatic Triple Negative Breast Cancer Receiving Gemcitabine and Carboplatin Chemotherapy (G1T28-04) (USO 16097)

Disease Types: Breast
Available at: Arlington Heights, Niles


A Phase III Randomized, Controlled Clinical Trial of Pembrolizumab with or without Platinum-Based Combination Chemotherapy Versus Chemotherapy in Subjects with Advanced or Metastatic Urothelial Carcinoma (USO 16054)

Disease Types: Bladder
Available at: Arlington Heights, Niles


Primary Objective of the Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry will Collect Data to Evaluate Safety Data Specific to the Use of Solaris and to Characterize the Progression of PNH as well as Clinical Outcomes, Mortality and Morbidity in Solaris and Non-Solaris Treated Patients. Secondary Objective is Raising PNH Awareness in the Medical Community and Patient/Potential Patient Population. (M07-001)(USO 08160)

Disease Types: Hematology, PNH
Available at: Arlington Heights, Niles